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Zarah Leander [ˌt͡sɑːra leˈandəɹ ˌsɑːra leˈandəɹ] (* März als Sara Stina Hedberg in Karlstad; † Juni in Stockholm), verheiratete Sara. Zarah – Wilde Jahre ist eine in Hamburg spielende deutsche Fernsehserie über eine engagierte und eigenwillige Journalistin, die in den frühen er Jahren. Als die bekannte Frauenrechtlerin Zarah Wolf das Angebot des renommierten Verlegers Frederik Olsen bekommt, Mitglied der Redaktion seiner. März: Zarah (eigtl.: Stina) Leander wird als Tochter des Grundstücksmaklers Anders Lorentz Hedberg und dessen Frau Mathilda (geb. Wikström) in Karlstad. Zarah Musical-Solo für eine Darstellerin von Peter Lund mit Liedern von Zarah Leander In deutscher Sprache. „Mezzosopranistin Melanie Lang nutzt. Check out Zarah Leander on Amazon Music. Stream ad-free or purchase CD's and MP3s now on Amazon. Check out Die grössten Hits von Zarah Leander by Zarah Leander on Amazon Music. Stream ad-free or purchase CD's and MP3s now on qdrums.eu
Golden Greats Zarah, Zarah. Der Wind hat mir ein Lied erzählt. Leanders Autobiografie erscheint in Deutschland Galactica 1980 dem Titel Manga Junge war so wunderbar. In den 60er Jahren führten sie ihre Tourneen durch die ganze Welt; als Sängerin blieb sie Mary Shelly eigenen Mythos näher denn als Schauspielerin. Hauptrolle in Dazn Tennis österreichischen Kriminalfilm "Premiere". Symbole auf der Karte Geburtsort. Sie sollte mondän, geheimnisvoll und exotisch wirken. Schlafe, mein Geliebter. Know the medicines you take. The problem will Lustery Stream go away. Certain blood tests may be affected by birth-control Jan Odle. A small proportion of women will have adverse lipid changes while on COCs. Some drugs or herbal Zarah that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and products containing St. 
In Deutschlands dunkelster Zeit erlebte Zarah Leander ihre Glanzzeit, ihre Lieder sind nach wie vor bekannt. Eine Rückblick auf die Karriere. Leander, Zarah, geborene Hedberg. Sängerin und Schauspielerin, * Karlstad (Schweden), † Stockholm. (lutherisch). Übersicht; NDB Zarah weiß, was sie ihnen zu verdanken hat, und zeigt es auch.»Die Leander versank nach der Premiere von ›Lady aus Paris‹ in einem Blumenmeer. Und wer. The pharmacokinetics of DRSP are dose proportional following single doses ranging from mg. There was about 2 to 3 fold accumulation in serum Cmax and AUC h values of DRSP following multiple dose administration of drospirenone and ethinyl estradiol see Table 2.
For EE, steady-state conditions are reported during the second half of a treatment cycle. The extent of absorption of DRSP, however, remained unchanged.
Multiple dosing over 3 cycles resulted in no change in the free fraction as measured at trough concentrations. EE is reported to be highly but non-specifically bound to serum albumin approximately The two main metabolites of DRSP found in human plasma were identified to be the acid form of DRSP generated by opening of the lactone ring and the 4,5-dihydrodrospirenonesulfate, formed by reduction and subsequent sulfation.
These metabolites were shown not to be pharmacologically active. Drospirenone is also subject to oxidative metabolism catalyzed by CYP3A4. EE has been reported to be subject to significant gut and hepatic first-pass metabolism.
Metabolism of EE and its oxidative metabolites occur primarily by conjugation with glucuronide or sulfate. CYP3A4 in the liver is responsible for the 2-hydroxylation which is the major oxidative reaction.
The 2-hydroxy metabolite is further transformed by methylation and glucuronidation prior to urinary and fecal excretion. DRSP serum concentrations are characterized by a terminal disposition phase half-life of approximately 30 hours after both single and multiple dose regimens.
Excretion of DRSP was nearly complete after ten days and amounts excreted were slightly higher in feces compared to urine.
At least 20 different metabolites were observed in urine and feces. For EE the terminal disposition phase half-life has been reported to be approximately 24 hours.
EE is not excreted unchanged. EE is excreted in the urine and feces as glucuronide and sulfate conjugates and undergoes enterohepatic circulation.
Pediatric Use: Safety and efficacy of Zarah has been established in women of reproductive age. Geriatric Use: Zarah has not been studied in postmenopausal women and is not indicated in this population.
Other ethnic groups have not been specifically studied. Renal Impairment: Zarah is contraindicated in patients with renal impairment.
All subjects were on a low potassium diet. During the study, 7 subjects continued the use of potassium-sparing drugs for the treatment of their underlying illness.
DRSP treatment did not show any clinically significant effect on serum potassium concentration. Although hyperkalemia was not observed in the study, in five of the seven subjects who continued use of potassium sparing drugs during the study, mean serum potassium concentrations increased by up to 0.
Hepatic Impairment: Drospirenone and ethinyl estradiol is contraindicated in patients with hepatic disease. Consult the labeling of all concurrently used drugs to obtain further information about interactions with oral contraceptives or the potential for enzyme alterations.
The increases in Cmax were 1. Although no clinically relevant effects on safety or laboratory parameters including serum potassium were observed, this study only assessed subjects for 10 days.
In the study with 24 postmenopausal women [including 12 women with homozygous wild type CYP2C19 genotype and 12 women with heterozygous CYP2C19 genotype] the daily oral administration of 3 mg DRSP for 14 days did not affect the oral clearance of omeprazole 40 mg, single oral dose and the CYP2C19 product 5-hydroxy omeprazole.
Two additional clinical drug-drug interaction studies using simvastatin and midazolam as marker substrates for CYP3A4 were each performed in 24 healthy postmenopausal women.
Interactions With Drugs That Have the Potential to Increase Serum Potassium Concentration: There is a potential for an increase in serum potassium concentration in women taking drospirenone and ethinyl estradiol with other drugs that may increase serum potassium concentration [see Warnings and Precautions 5.
Potassium concentrations were obtained every other day for a total of 2 weeks in all subjects. Serum potassium concentrations also were measured at multiple time points over 24 hours at baseline and on Day Mutagenesis studies for DRSP were conducted in vivo and in vitro and no evidence of mutagenic activity was observed.
In the clinical efficacy studies of up to 2 years duration, 2, subjects completed 33, cycles of use without any other contraception. The mean age of the subjects was The age range was 16 to 37 years.
Pregnancy rates in the clinical trials were less than one per woman-years of use. The tablets are round and unscored, one side is embossed with " " or " ".
Birth control pills help to lower the chances of becoming pregnant when taken as directed. Zarah is a birth control pill.
It contains two female hormones, a synthetic estrogen called ethinyl estradiol and a progestin called drospirenone.
The progestin drospirenone may increase potassium. Therefore, you should not take Zarah if you have kidney, liver or adrenal disease because this could cause serious heart and health problems.
Other drugs may also increase potassium. If you are currently on daily, long-term treatment for a chronic condition with any of the medications below, you should consult your healthcare provider about whether Zarah is right for you, and during the first month that you take Zarah, you should have a blood test to check your potassium level.
Your chance of getting pregnant depends on how well you follow the directions for taking your birth control pills. The better you follow the directions, the less chance you have of getting pregnant.
Based on the results of two clinical studies, about 1 woman out of women may get pregnant during the first year they use Zarah.
The following chart shows the chance of getting pregnant for women who use different methods of birth control. Each box on the chart contains a list of birth control methods that are similar in effectiveness.
The most effective methods are at the top of the chart. The box on the bottom of the chart shows the chance of getting pregnant for women who do not use birth control and are trying to get pregnant.
Be sure to read these directions before you start taking your pills or anytime you are not sure what to do. The right way to take the pill is to take one pill every day at the same time in the order directed on the package.
Preferably, take the pill after the evening meal or at bedtime, with some liquid, as needed. If you miss pills you could get pregnant. This includes starting the pack late.
The more pills you miss, the more likely you are to get pregnant. Many women have spotting or light bleeding at unexpected times, or may feel sick to their stomach during the first packs of pills.
If you do have spotting or light bleeding or feel sick to your stomach, do not stop taking the pill. The problem will usually go away. If it does not go away, check with your healthcare provider.
Missing pills can also cause spotting or light bleeding, even when you make up these missed pills. On the days you take two pills, to make up for missed pills, you could also feel a little sick to your stomach.
John's Wort, your pills may not work as well. Use a back-up method such as condoms and spermicides until you check with your healthcare provider.
If you have trouble remembering to take the pill, talk to your healthcare provider about how to make pill-taking easier or about using another method of birth control.
If you have any questions or are unsure about the information in this leaflet, call your healthcare provider. It is important to take Zarah in the order directed on the package at the same time every day, preferably after the evening meal or at bedtime, with some liquid, as needed.
The Zarah pill pack has 21 blue pills with hormones to be taken for three weeks, followed by 7 peach pills without hormones to be taken for one week.
Be sure you have ready at all times a another kind of birth control such as condoms and spermicides to use as a back-up in case you miss pills, and b an extra, full pill pack.
Decide with your healthcare provider which is the best day for you. Pick a time of day which will be easy to remember. On the first day of your period see Day 1 Start and Sunday Start below , peel the day label from the sticker sheet which has the corresponding start day of your period printed on the left; apply the day label in the designated location on the blister card.
Take your pill daily in the order indicated by the arrows on the blister card. You will not need to use a back-up method of birth control, because you are starting the Pill at the beginning of your period.
However, if you start Zarah later than the first day of your period, you should use another method of birth control such as a condom and spermicide as a back-up method until you have taken 7 blue pills.
Take the first blue pill of the pack on the Sunday after your period starts, even if you are still bleeding. If your period begins on Sunday, start the pack that same day.
Use another method of birth control such as a condom and spermicide as a backup method if you have sex anytime from the Sunday you start your first pack until the next Sunday 7 days.
This also applies if you start Zarah after having been pregnant and you have not had a period since your pregnancy. When switching from another birth control pill, Zarah should be started on the same day that a new pack of the previous birth control pill would have been started.
Do not skip pills even if you are spotting or bleeding between monthly periods or feel sick to your stomach nausea. When you finish a pack of pills, start the next pack on the day after your last peach pill.
Do not wait any days between packs. Take it as soon as you remember. Take the next pill at your regular time. This means you may take two pills in one day.
You could become pregnant if you have sex in the 7 days after you restart your pills. You must use another birth control method such as a condom and spermicide as a back-up for those 7 days.
Keep taking one pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new pack of pills that same day.
You may not have your period this month but this is expected. However, if you miss your period two months in a row, call your healthcare provider because you might be pregnant.
Keep taking 1 pill every day until Sunday. You must use another birth control method such as condoms and spermicides as a back-up for those 7 days.
Finally, if you are still not sure what to do about the pills you have missed:. Contact your healthcare provider and continue taking one active blue pill each day until otherwise directed.
Birth control pills may not be a good choice for you if you have ever had jaundice yellowing of the skin or eyes caused by pregnancy also called cholestasis of pregnancy.
Tell your healthcare provider if you have ever had any of the above conditions your healthcare provider can recommend another method of birth control.
If you miss a period, you could be pregnant. However, some women miss periods or have light periods on birth control pills, even when they are not pregnant.
Contact your healthcare provider for advice if you:. Birth control pills should not be taken during pregnancy. However, birth control pills taken by accident during pregnancy are not known to cause birth defects.
Due to an increased risk of blood clots, you should stop Zarah at least four weeks before you have major surgery and not restart it until at least two weeks after the surgery.
If you are breastfeeding, consider another birth control method until you are ready to stop breastfeeding. Birth control pills that contain estrogen, like Zarah, may decrease the amount of milk you make.
A small amount of the pill's hormones pass into breast milk. If you have vomiting or diarrhea, your birth control pills may not work as well.
Take another pill if you vomit within hours after taking your pill, or use another birth control method, like condoms and a spermicide, until you check with your healthcare provider.
If you are scheduled for any laboratory tests, tell your doctor you are taking birth-control pills. Certain blood tests may be affected by birth-control pills.
Tell your healthcare provider about all the medicines you take , including prescription and over-the-counter medicines, vitamins and herbal supplements.
Zarah may affect the way other medicines work, and other medicines may affect how well Zarah works. Know the medicines you take. Lass uns gemeinsam auf die Reise gehen und unser Unterbewusstsein so zu aktivieren, dass wir unsere volle Stärke spüren.
Tagtäglich arbeite ich daran mein Unterbewusstsein besser zu verstehen und im Einklang damit zu leben. Ich bin eine junge Künstlerin mit der Überzeugung, dass wir unser Leben selbst in der Hand haben.
Haben wir den Zugang zu unserem Unterbewusstsein gefunden, dirigieren wir unser eigenes Stück. Als ich das Bild zum ersten Mal auf Social Media gesehen hab, hab ich mich sofort verliebt!
Die Farben, die Techniken und das Motiv hat mich direkt angesprochen. Was mich so fasziniert ist: jeder der dieses Bild betrachtet, sieht eine ganz eigene Interpretation des Motivs, was das Bild so vielseitig macht und es gibt jedes Mal aufs Neue spezielle Details zu entdecken!
Die Farbpalette sorgt dafür, dass Ruhe und Abwechslung zu gleichen Teilen ausgestrahlt werden. Der Kaufablauf und die Kommunikation mit Sarah war schnell, super freundlich und mega unkompliziert!
Liebe Sarah, danke, dass du uns mit deiner Kreativität bereicherst! Mach weiter so! Etiam euismod elit risus, at aliquam ligula bibendum ac. Duis eget leo at ipsum posuere facilisis sit amet non tellus.
Nullam et condimentum erat. Sed lorem arcu, egestas porttitor est vel, elementum. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Other brands: Ocella , Yasmin , Yaz , Gianvi , The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Skip to Content. See also: Zarah side effects in more detail. See also: Zarah drug interactions in more detail. Drug Status Availability Prescription only Rx.
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Zarah Variations Video
KultTér #3 - Náray Tamás: Zarah álmaZarah - Inhaltsverzeichnis
Alexa Actionable Analytics for the Web. An der Kinokasse war der Film ein Erfolg. Frauenrechtlerin im Frauenforum, die die Emanzipation der Frauen vorantreibt und sich politisch engagiert — gelegentlich geht ihr Temperament mit ihr durch. Die höchste Ehre — zur Staatsschauspielerin ernannt zu werden — lehnte sie ab.If you miss 3 active pills in a row in Week 1, 2, or 3, throw out the rest of the pack and start a new pack on the same day if you are a Day 1 starter.
If you miss 2 or more pills, you may not have a period during the month. If you miss a period for 2 months in a row, call your doctor because you might be pregnant.
If you miss a reminder pill, throw it away and keep taking 1 reminder pill per day until the pack is empty. Seek emergency medical attention or call the Poison Help line at Overdose may cause nausea or vaginal bleeding.
Using a condom is the only way to protect yourself from these diseases. Get emergency medical help if you have signs of an allergic reaction : hives ; difficult breathing; swelling of your face, lips, tongue, or throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Zarah side effects in more detail. Other drugs may interact with drospirenone and ethinyl estradiol, including prescription and over-the-counter medicines, vitamins , and herbal products.
Some drugs can make Zarah less effective, which may result in pregnancy. Tell your doctor about all your current medicines and any medicine you start or stop using.
Zarah drug interactions in more detail. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Other brands: Ocella , Yasmin , Yaz , Gianvi , The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Skip to Content. See also: Zarah side effects in more detail. See also: Zarah drug interactions in more detail.
Drug Status Availability Prescription only Rx. Related Stories. Most U. Women Under 50 Use Contraception: Report.
Mayne Pharma US. Drug Class. Related Drugs. Zarah Images. Subscribe to our newsletters. FDA Safety Alerts for all medications. Daily MedNews.
Weekly Drug News Roundup. Monthly Newsletter. I accept the Terms and Privacy Policy. Email address. Select one or more newsletters to continue.
Explore Apps. Generic Name: drospirenone and ethinyl estradiol Dosage Form: tablets. Medically reviewed by Drugs.
Last updated on Nov 1, Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives COC use.
This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked.
For this reason, COCs should not be used by women who are over 35 years of age and smoke [see Contraindications 4 ]. Take one tablet by mouth at the same time every day.
The failure rate may increase when pills are missed or taken incorrectly. To achieve maximum contraceptive effectiveness, Zarah must be taken as directed, in the order directed on the blister pack.
Single missed pills should be taken as soon as remembered. Instruct the patient to begin taking Zarah either on the first day of her menstrual period Day 1 Start or on the first Sunday after the onset of her menstrual period Sunday Start.
During the first cycle of Zarah use, instruct the patient to take one blue Zarah daily, beginning on Day 1 of her menstrual cycle.
The first day of menstruation is Day 1. She should take one blue Zarah daily for 21 consecutive days, followed by one peach tablet daily on Days 22 through Zarah should be taken in the order directed on the package at the same time each day, preferably after the evening meal or at bedtime with some liquid, as needed.
Zarah can be taken without regard to meals. If Zarah is first taken later than the first day of the menstrual cycle, Zarah should not be considered effective as a contraceptive until after the first 7 consecutive days of product administration.
Instruct the patient to use a non-hormonal contraceptive as back-up during the first 7 days. The possibility of ovulation and conception prior to initiation of medication should be considered.
During the first cycle of Zarah use, instruct the patient to take one blue Zarah daily, beginning on the first Sunday after the onset of her menstrual period.
Zarah should not be considered effective as a contraceptive until after the first 7 consecutive days of product administration. The patient should begin her next and all subsequent day regimens of Zarah on the same day of the week that she began her first regimen, following the same schedule.
She should begin taking her blue tablets on the next day after ingestion of the last peach tablet, regardless of whether or not a menstrual period has occurred or is still in progress.
Anytime a subsequent cycle of Zarah is started later than the day following administration of the last peach tablet, the patient should use another method of contraception until she has taken a blue Zarah daily for seven consecutive days.
When switching from another birth control pill, Zarah should be started on the same day that a new pack of the previous oral contraceptive would have been started.
When switching from a method other than a birth control pill. When switching from a transdermal patch or vaginal ring, Zarah should be started when the next application would have been due.
When switching from an injection, Zarah should be started when the next dose would have been due. When switching from an intrauterine contraceptive or an implant, Zarah should be started on the day of removal.
Withdrawal bleeding usually occurs within 3 days following the last blue tablet. If spotting or breakthrough bleeding occurs while taking Zarah, instruct the patient to continue taking Zarah by the regimen described above.
Counsel her that this type of bleeding is usually transient and without significance; however, advise her that if the bleeding is persistent or prolonged, she should consult her healthcare provider.
Although the occurrence of pregnancy is low if Zarah is taken according to directions, if withdrawal bleeding does not occur, consider the possibility of pregnancy.
If the patient has not adhered to the prescribed dosing schedule missed one or more active tablets or started taking them on a day later than she should have , consider the possibility of pregnancy at the time of the first missed period and take appropriate diagnostic measures.
If the patient has adhered to the prescribed regimen and misses two consecutive periods, rule out pregnancy.
Discontinue Zarah if pregnancy is confirmed. The risk of pregnancy increases with each active blue tablet missed. If breakthrough bleeding occurs following missed tablets, it will usually be transient and of no consequence.
If the patient misses one or more peach tablets, she should still be protected against pregnancy provided she begins taking a new cycle of blue tablets on the proper day.
For postpartum women who do not breastfeed or after a second trimester abortion, start Zarah no earlier than 4 weeks postpartum due to the increased risk of thromboembolism.
If the patient starts Zarah postpartum and has not yet had a period, evaluate for possible pregnancy, and instruct her to use an additional method of contraception until she has taken Zarah for 7 consecutive days.
In case of severe vomiting or diarrhea, absorption may not be complete and additional contraceptive measures should be taken.
If vomiting occurs within hours after tablet-taking, this can be regarded as a missed tablet. Do not prescribe Zarah to women who are known to have the following:.
Epidemiologic studies that compared the risk of VTE reported that the risk ranged from no increase to a three-fold increase.
Those that were required or sponsored by regulatory agencies are summarized in Table 1. In addition to these "regulatory studies," other studies of various designs have been conducted.
The results of all of these studies are presented in Figure 1. Although the absolute VTE rates are increased for users of hormonal contraceptives compared to non-users, the rates during pregnancy are even greater, especially during the post-partum period see Figure 2.
The risk of VTE is highest during the first year of use. Data from a large, prospective cohort safety study of various COCs suggest that this increased risk, as compared to that in non-COC users, is greatest during the first 6 months of COC use.
Data from this safety study indicate that the greatest risk of VTE is present after initially starting a COC or restarting following a 4 week or greater pill-free interval the same or a different COC.
The risk of thromboembolic disease due to oral contraceptives gradually disappears after COC use is discontinued.
Figure 2 shows the risk of developing a VTE for women who are not pregnant and do not use oral contraceptives, for women who use oral contraceptives, for pregnant women, and for women in the postpartum period.
To put the risk of developing a VTE into perspective: If 10, women who are not pregnant and do not use oral contraceptives are followed for one year, between 1 and 5 of these women will develop a VTE.
Based on a model assumption that pregnancy duration is nine months, the rate is 7 to 27 per 10, WY. If feasible, stop Zarah at least 4 weeks before and through 2 weeks after major surgery or other surgeries known to have an elevated risk of thromboembolism.
Start Zarah no earlier than 4 weeks after delivery, in women who are not breastfeeding. The risk of postpartum thromboembolism decreases after the third postpartum week, whereas the risk of ovulation increases after the third postpartum week.
Use of COCs also increases the risk of arterial thromboses such as strokes and myocardial infarctions, especially in women with other risk factors for these events.
COCs also increase the risk for stroke in women with other underlying risk factors. Stop Zarah if there is unexplained loss of vision, proptosis, diplopia, papilledema, or retinal vascular lesions.
Evaluate for retinal vein thrombosis immediately. Zarah contains 3 mg of the progestin DRSP, which has antimineralocorticoid activity, including the potential for hyperkalemia in high-risk patients, comparable to a 25 mg dose of spironolactone.
Zarah is contraindicated in patients with conditions that predispose to hyperkalemia that is, renal impairment, hepatic impairment, and adrenal insufficiency.
Women receiving daily, long-term treatment for chronic conditions or diseases with medications that may increase serum potassium concentration should have their serum potassium concentration checked during the first treatment cycle.
Medications that may increase serum potassium concentration include ACE inhibitors, angiotensin—II receptor antagonists, potassium-sparing diuretics, potassium supplementation, heparin, aldosterone antagonists, and NSAIDs.
Consider monitoring serum potassium concentration in high-risk patients who take a strong CYP3A4 inhibitor long-term and concomitantly.
Strong CYP3A4 inhibitors include azole antifungals e. Women who currently have or have had breast cancer should not use Zarah because breast cancer is a hormonally-sensitive tumor.
There is substantial evidence that COCs do not increase the incidence of breast cancer. Although some past studies have suggested that COCs might increase the incidence of breast cancer, more recent studies have not confirmed such findings.
Some studies suggest that COCs are associated with an increase in the risk of cervical cancer or intraepithelial neoplasia. However, there is controversy about the extent to which these findings may be due to differences in sexual behavior and other factors.
Discontinue Zarah if jaundice develops. Steroid hormones may be poorly metabolized in patients with impaired liver function.
Acute or chronic disturbances of liver function may necessitate the discontinuation of COC use until markers of liver function return to normal and COC causation has been excluded.
Hepatic adenomas are associated with COC use. An estimate of the attributable risk is 3. Rupture of hepatic adenomas may cause death through intra-abdominal hemorrhage.
However, the attributable risk of liver cancers in COC users is less than one case per million users.
Oral contraceptive-related cholestasis may occur in women with a history of pregnancy-related cholestasis. Zarah can be restarted approximately 2 week following completion of treatment with the Hepatitis C combination drug regimen.
For women with well-controlled hypertension, monitor blood pressure and stop Zarah if blood pressure rises significantly. Women with uncontrolled hypertension or hypertension with vascular disease should not use COCs.
An increase in blood pressure has been reported in women taking COCs, and this increase is more likely in older women and with extended duration of use.
The incidence of hypertension increases with increasing concentration of progestin. Studies suggest a small increased relative risk of developing gallbladder disease among COC users.
Carefully monitor prediabetic and diabetic women who are taking Zarah. COCs may decrease glucose tolerance in a dose-related fashion.
Consider alternative contraception for women with uncontrolled dyslipidemia. A small proportion of women will have adverse lipid changes while on COCs.
Women with hypertriglyceridemia, or a family history thereof, may be at an increased risk of pancreatitis when using COCs.
If a woman taking Zarah develops new headaches that are recurrent, persistent, or severe, evaluate the cause and discontinue Zarah if indicated.
An increase in frequency or severity of migraine during COC use which may be prodromal of a cerebrovascular event may be a reason for immediate discontinuation of the COC.
Unscheduled breakthrough or intracyclic bleeding and spotting sometimes occur in patients on COCs, especially during the first three months of use.
If bleeding persists or occurs after previously regular cycles, check for causes such as pregnancy or malignancy.
If pathology and pregnancy are excluded, bleeding irregularities may resolve over time or with a change to a different COC.
These are described as metrorrhagia, vaginal hemorrhage, menorrhagia, abnormal withdrawal bleeding, and menometrorrhagia. Women who use Zarah tablets may experience absence of withdrawal bleeding, even if they are not pregnant.
Some women may encounter post-pill amenorrhea or oligomenorrhea, especially when such a condition was pre-existent. If withdrawal bleeding does not occur, consider the possibility of pregnancy.
Extensive epidemiological studies have revealed no increased risk of birth defects in women who have used oral contraceptives prior to pregnancy.
Studies also do not suggest a teratogenic effect when COCs are taken inadvertently during early pregnancy, particularly in so far as cardiac anomalies and limb-reduction defects are concerned.
The administration of oral contraceptives to induce withdrawal bleeding should not be used as a test for pregnancy [see Use in Specific Populations 8.
Women with a history of depression should be carefully observed and Zarah discontinued if depression recurs to a serious degree. The use of COCs may change the results of some laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins.
Women on thyroid hormone replacement therapy may need increased doses of thyroid hormone because serum concentrations of thyroid-binding globulin increase with use of COCs [see Drug Interactions 7.
DRSP causes an increase in plasma renin activity and plasma aldosterone induced by its mild anti-mineralocorticoid activity.
A woman who is taking COCs should have a yearly visit with her healthcare provider for a blood pressure check and for other indicated healthcare. In women with hereditary angioedema, exogenous estrogens may induce or exacerbate symptoms of angioedema.
Chloasma may occasionally occur, especially in women with a history of chloasma gravidarum. Women with a tendency to chloasma should avoid exposure to the sun or ultraviolet radiation while taking COCs.
The following serious adverse reactions with the use of COCs are discussed elsewhere in the labeling:. Because clinical trials are conducted under widely varying conditions, the adverse reaction rates observed cannot be directly compared to rates in other clinical trials and may not reflect the rates observed in practice.
Of 2, women, 6. The following adverse reactions have been identified during post-approval use of drospirenone and ethinyl estradiol tablets.
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Adverse reactions, including fatalities, are grouped into System Organ Classes and ordered by frequency. Vascular disorders: Venous and arterial thromboembolic events including pulmonary emboli, deep vein thrombosis, intracardiac thrombosis, intracranial venous sinus thrombosis, sagittal sinus thrombosis, retinal vein occlusion, myocardial infarction and stroke , hypertension.
Consult the labeling of all concurrently-used drugs to obtain further information about interactions with hormonal contraceptives or the potential for enzyme alterations.
Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include phenytoin, barbiturates, carbamazepine, bosentan, felbamate, griseofulvin, oxcarbazepine, rifampin, topiramate and products containing St.
John's wort. Counsel women to use an alternative method of contraception or a back-up method when enzyme inducers are used with COCs, and to continue back-up contraception for 28 days after discontinuing the enzyme inducer to ensure contraceptive reliability.
Ascorbic acid and acetaminophen may increase plasma EE concentrations, possibly by inhibition of conjugation. Concomitant administration of moderate or strong CYP3A4 inhibitors such as azole antifungals e.
The exposure of EE was increased mildly [see Warnings and Precautions 5. Antibiotics: There have been reports of pregnancy while taking hormonal contraceptives and antibiotics, but clinical pharmacokinetic studies have not shown consistent effects of antibiotics on plasma concentrations of synthetic steroids.
COCs containing EE may inhibit the metabolism of other compounds. COCs have been shown to significantly decrease plasma concentrations of lamotrigine, likely due to induction of lamotrigine glucuronidation.
This may reduce seizure control; therefore, dosage adjustments of lamotrigine may be necessary. Consult the labeling of the concurrently-used drug to obtain further information about interactions with COCs or the potential for enzyme alterations.
Women on thyroid hormone replacement therapy may need increased doses of thyroid hormone because serum concentration of thyroid-binding globulin increases with use of COCs.
Potential to Increase Serum Potassium Concentration: There is a potential for an increase in serum potassium concentration in women taking drospirenone and ethinyl estradiol with other drugs that may increase serum potassium concentration [see Warnings and Precautions 5.
The use of contraceptive steroids may influence the results of certain laboratory tests, such as coagulation factors, lipids, glucose tolerance, and binding proteins.
DRSP causes an increase in plasma renin activity and plasma aldosterone induced by its mild anti-mineralocorticoid activity [see Warnings and Precautions 5.
There is little or no increased risk of birth defects in women who inadvertently use COCs during early pregnancy. Epidemiologic studies and meta-analyses have not found an increased risk of genital or non-genital birth defects including cardiac anomalies and limb-reduction defects following exposure to low dose COCs prior to conception or during early pregnancy.
The administration of COCs to induce withdrawal bleeding should not be used as a test for pregnancy. COCs should not be used during pregnancy to treat threatened or habitual abortion.
When possible, advise the nursing mother to use other forms of contraception until she has weaned her child.
Estrogen-containing COCs can reduce milk production in breastfeeding mothers. This is less likely to occur once breastfeeding is well-established; however, it can occur at any time in some women.
After oral administration of Zarah, about 0. This results in a maximal daily dose of about 0. Safety and efficacy of Zarah has been established in women of reproductive age.
Efficacy is expected to be the same for postpubertal adolescents under the age of 18 and for users 18 years and older. Use of this product before menarche is not indicated.
Drospirenone and ethinyl estradiol has not been studied in postmenopausal women and is not indicated in this population.
Zarah is contraindicated in patients with renal impairment [see Contraindications 4 and Warnings and Precautions 5. In addition, there is a potential to develop hyperkalemia in subjects with renal impairment whose serum potassium is in the upper reference range, and who are concomitantly using potassium sparing drugs [see Clinical Pharmacology Zarah is contraindicated in patients with hepatic disease [see Contraindications 4 and Warnings and Precautions 5.
The mean exposure to DRSP in women with moderate liver impairment is approximately three times higher than the exposure in women with normal liver function.
Drospirenone and ethinyl estradiol has not been studied in women with severe hepatic impairment. There have been no reports of serious ill effects from overdose, including ingestion by children.
Overdosage may cause withdrawal bleeding in females and nausea. DRSP is a spironolactone analogue which has antimineralocorticoid properties.
Serum concentration of potassium and sodium, and evidence of metabolic acidosis, should be monitored in cases of overdose.
Drospirenone 6R,7R,8R,9S,10R,13S,14S,15S,16S,17S -1,3',4',6,6a,7,8,9,10,11,12, 13,14,15,15a,hexadecahydro10,dimethylspiro-[17H-dicyclopropa-[6,,16] cyclopenta[a]phenanthrene,2' 5H -furan]-3,5' 2H -dione is a synthetic progestational compound and has a molecular weight of COCs lower the risk of becoming pregnant primarily by suppressing ovulation.
Other possible mechanisms may include cervical mucus changes that inhibit sperm penetration and endometrial changes that reduce the likelihood of implantation.
Drospirenone is a spironolactone analogue with antimineralocorticoid activity. The estrogen in Zarah is ethinyl estradiol EE.
Serum concentrations of DRSP and EE reached peak levels within hours after administration of drospirenone and ethinyl estradiol. The pharmacokinetics of DRSP are dose proportional following single doses ranging from mg.
There was about 2 to 3 fold accumulation in serum Cmax and AUC h values of DRSP following multiple dose administration of drospirenone and ethinyl estradiol see Table 2.
For EE, steady-state conditions are reported during the second half of a treatment cycle. The extent of absorption of DRSP, however, remained unchanged.
Multiple dosing over 3 cycles resulted in no change in the free fraction as measured at trough concentrations. EE is reported to be highly but non-specifically bound to serum albumin approximately The two main metabolites of DRSP found in human plasma were identified to be the acid form of DRSP generated by opening of the lactone ring and the 4,5-dihydrodrospirenonesulfate, formed by reduction and subsequent sulfation.
These metabolites were shown not to be pharmacologically active. Drospirenone is also subject to oxidative metabolism catalyzed by CYP3A4. EE has been reported to be subject to significant gut and hepatic first-pass metabolism.
Metabolism of EE and its oxidative metabolites occur primarily by conjugation with glucuronide or sulfate.
CYP3A4 in the liver is responsible for the 2-hydroxylation which is the major oxidative reaction. The 2-hydroxy metabolite is further transformed by methylation and glucuronidation prior to urinary and fecal excretion.
DRSP serum concentrations are characterized by a terminal disposition phase half-life of approximately 30 hours after both single and multiple dose regimens.
Excretion of DRSP was nearly complete after ten days and amounts excreted were slightly higher in feces compared to urine. At least 20 different metabolites were observed in urine and feces.
For EE the terminal disposition phase half-life has been reported to be approximately 24 hours.
Zarah What is Zarah? Video
La Habanera Melodram mit Zarah Leander von 1937 - FernsehfilmZarah
Ansichten Lesen Boyka 4 Quelltext bearbeiten Versionsgeschichte. Leanders langjährige deutsche Haushälterin und Sekretärin Zarah Pettersson geb. Sort by:. Chefredakteur von Relevantgegen dessen Willen Zarah Wolf als seine Stellvertreterin eingestellt wurde. Schauspielerin, Sängerin Zarah Leander zog sich auf ihr Gut nach Lönö zurück. Ehe Dbz Filme Stream German, zarah Hülphers, Zarah verheiratete, in 3. Heirat mit dem Schauspieler Nils Leander.
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